Does Coffee Cause Inflammation? Exploring the Research.

By Last Updated: October 30th, 20239.4 min readViews: 2889

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About the Author: Daryl Stubbs
Daryl Stubbs
Daryl Stubbs is a multi-disciplinary health professional, combining his roles as an award-winning athletic therapist, registered massage therapist, and certified holistic nutritionist to offer a comprehensive approach to wellness. Graduating in 2013, Daryl has been recognized as the best massage therapy clinic in Victoria for 2022 and 2023 and has received national athletic therapy awards. He is known for his holistic approach to health, focusing on treating the body as a whole. Clients appreciate his focus on the science of probiotics, supplements, gut health, and the human body, ensuring a well-informed and evidence-based approach to their wellness journey.

Coffee is one of the most popular beverages worldwide, and its consumption has been linked to several health benefits. However, some studies have suggested that coffee may cause inflammation, leading to concerns about its impact on health. Inflammation is the body’s response to harmful stimuli, such as pathogens or damaged cells, and it plays a role in several chronic diseases.

Some researchers have suggested that caffeine, one of the main active compounds in coffee, may contribute to inflammation by increasing the production of stress hormones such as cortisol. Others argue that coffee contains antioxidants and other bioactive compounds that have anti-inflammatory properties, which may counteract any potential pro-inflammatory effects of caffeine. Therefore, the question of whether coffee causes inflammation remains a topic of debate in the scientific community.

Key TakeAway If Coffee Can Cause Inflammation?

There is some evidence to suggest that coffee may increase inflammation in some people, but for most people, coffee does not cause inflammation and may even have anti-inflammatory effects.

Coffee beans contain antioxidants and other health-promoting plant compounds that can neutralize inflammatory free radicals, thereby lowering systemic inflammation.

However, coffee consumption can spike cortisol levels, which is anti-inflammatory by nature, but prolonged levels can have the opposite effect, contributing to chronic inflammation.

Some studies have found that caffeine can increase levels of inflammatory markers, while others have found that coffee consumption has predominantly anti-inflammatory effects.

Overall, the effects of coffee on inflammation are complex and may vary depending on individual genetics and other factors.

If you are concerned about coffee increasing inflammation, you can look into try mushroom coffee. It’s paired with medicinal mushrooms, like reishi, that reduces inflammation. Four Sigmatic is our favourite mushroom coffee brand.

What is Inflammation?

Inflammation is a natural response of the body’s immune system to injury, infection, or tissue damage. It is a complex process that involves various cells, chemicals, and molecular pathways. The primary purpose of inflammation is to protect the body from harmful stimuli and to initiate the healing process. However, when inflammation becomes chronic or excessive, it can lead to tissue damage and contribute to the development of various diseases, such as arthritis, heart disease, diabetes, and cancer.

Acute inflammation is a short-term response that occurs immediately after an injury or infection. It is characterized by redness, swelling, heat, and pain. The immune system releases white blood cells, such as neutrophils and macrophages, to the site of injury or infection to neutralize the threat and remove damaged tissue. Once the threat is eliminated, the inflammation subsides, and the healing process begins.

Chronic inflammation, on the other hand, is a long-term response that persists even after the threat has been eliminated. It is often caused by lifestyle factors, such as a poor diet, lack of exercise, stress, and exposure to environmental toxins. Chronic inflammation can lead to the accumulation of damaged cells and tissues, which can contribute to the development of chronic diseases.

The Science Behind Coffee and Inflammation

Caffeine and Inflammation

Caffeine is a natural stimulant found in coffee that can cause an increase in heart rate, blood pressure, and cortisol levels. Some studies have suggested that caffeine may contribute to inflammation. However, other studies have shown that caffeine can also have anti-inflammatory effects. The effects of caffeine on inflammation may depend on a person’s genetics, age, and overall health.

Antioxidants in Coffee

Coffee contains several active compounds with antioxidant properties, including polyphenols and chlorogenic acid. These antioxidants can help protect the body against oxidative stress, which can lead to inflammation. Studies have shown that regular coffee consumption may be associated with lower levels of inflammation in the body.

Other Compounds in Coffee

Coffee also contains other compounds that may have anti-inflammatory effects, such as trigonelline and caffeine metabolites. These compounds may help reduce inflammation and protect against certain diseases.

Overall, the relationship between coffee and inflammation is complex and may depend on a variety of factors. While coffee may have some anti-inflammatory effects, it is important to consume coffee in moderation and as part of a balanced diet.

Studies on Coffee and Inflammation

Human Studies

Several studies have investigated the relationship between coffee consumption and inflammation in humans. One study published in the American Journal of Clinical Nutrition found that individuals who drank three to five cups of coffee per day had lower levels of C-reactive protein (CRP), a marker of inflammation, compared to those who drank less than one cup per day.

Another study published in the Journal of Nutrition found that coffee consumption was associated with lower levels of interleukin-6 (IL-6), a pro-inflammatory cytokine. The study also found that the anti-inflammatory effects of coffee were more pronounced in women than in men.

However, not all studies have found a clear association between coffee consumption and inflammation. A study published in the European Journal of Clinical Nutrition found no significant association between coffee consumption and markers of inflammation, such as CRP and IL-6, in a large sample of Finnish adults.

Animal Studies

Animal studies have also been conducted to investigate the effects of coffee on inflammation. One study published in the Journal of Agricultural and Food Chemistry found that coffee consumption reduced inflammation in mice with colitis, a type of inflammatory bowel disease.

Another study published in the Journal of Medicinal Food found that coffee extract reduced inflammation in rats with liver damage. The study also found that coffee extract increased levels of antioxidant enzymes, which may help protect against oxidative stress and inflammation.

While animal studies can provide valuable insights into the potential effects of coffee on inflammation, it is important to note that the results may not always translate to humans. Further research is needed to fully understand the relationship between coffee consumption and inflammation in both humans and animals.

Potential Benefits of Coffee for Inflammation

Reduced Risk of Chronic Diseases

Coffee contains active compounds with antioxidant and anti-inflammatory properties that may help reduce low-grade inflammation and protect against certain diseases. According to a study published in the Journal of Nutrition, drinking coffee may reduce the risk of chronic diseases such as type 2 diabetes, cardiovascular disease, and some types of cancer.

Another study published in the American Journal of Clinical Nutrition found that coffee consumption was associated with a lower risk of mortality from inflammatory diseases such as respiratory disease, stroke, and diabetes.

Improved Cognitive Function

Caffeine, the main active ingredient in coffee, is a stimulant that can improve cognitive function, including memory, attention, and reaction time. A study published in the Journal of Alzheimer’s Disease found that caffeine intake was associated with a lower risk of cognitive decline and dementia in older adults.

Additionally, coffee contains other compounds such as chlorogenic acid and trigonelline that have been shown to have neuroprotective effects and may help reduce inflammation in the brain.

Reduced Pain

Caffeine has been shown to have pain-relieving properties and can enhance the effects of pain medications. A study published in the Journal of Pain found that caffeine intake was associated with a reduction in pain sensitivity and improved pain relief in individuals with chronic pain.

Furthermore, coffee contains anti-inflammatory compounds such as polyphenols that may help reduce inflammation and pain in conditions such as osteoarthritis and rheumatoid arthritis.

While coffee may have potential benefits for reducing inflammation, it is important to note that excessive consumption of caffeine can have negative effects such as increased anxiety, jitters, and disrupted sleep. It is recommended to limit coffee intake to one to two cups per day and to avoid adding sugar or creamer, which can increase inflammation in the body.

Potential Risks of Coffee for Inflammation

Increased Heart Rate and Blood Pressure

Caffeine is a stimulant that can increase heart rate and blood pressure. For some people, this effect may be more pronounced, especially if they consume large amounts of coffee or have underlying heart conditions. High blood pressure is a risk factor for inflammation and chronic diseases, so it is important to monitor your coffee intake and talk to your doctor if you have any concerns.

Insomnia and Anxiety

Caffeine can also interfere with sleep and cause anxiety in some people. Lack of sleep and chronic stress are both known to increase inflammation in the body, so it is important to be mindful of how much caffeine you consume and when you consume it. If you have trouble sleeping or experience anxiety after drinking coffee, consider reducing your intake or switching to decaf.

Acid Reflux and Stomach Problems

Coffee is known to stimulate the production of stomach acid, which can lead to acid reflux and other digestive problems. Acid reflux is a risk factor for inflammation in the esophagus and can lead to complications such as Barrett’s esophagus and esophageal cancer. If you experience acid reflux or other stomach problems after drinking coffee, consider switching to a low-acid coffee or reducing your intake.

Overall, coffee can have both positive and negative effects on inflammation depending on the individual and the amount consumed. It is important to be mindful of your coffee intake and listen to your body to determine what works best for you.


While there is no definitive answer to whether coffee causes inflammation or not, research suggests that moderate coffee intake may have anti-inflammatory effects in the body. Drinking coffee in small amounts may help reduce inflammation, which may lower the risk of certain conditions, including type 2 diabetes, heart disease, Alzheimer’s, Parkinson’s, gout, and some cancers.

However, it’s important to note that excessive coffee consumption may have negative effects on health, including increased heart rate, jitters, and sleep disturbance. Additionally, people with cardiovascular issues or diseases should be cautious about consuming coffee.

Therefore, it’s recommended to limit coffee intake to one to two cups per day or switch to decaf to avoid the negative effects of caffeine. Furthermore, people with existing health conditions should consult with their doctor before making any significant changes to their diet.

Does Coffee Cause Inflammation?

There is much debate about whether coffee causes inflammation in the body. Some studies suggest that coffee may actually have anti-inflammatory effects, while others argue that caffeine can contribute to inflammation by disrupting natural cortisol levels and sleep patterns.

It is important to note that the impact of coffee on inflammation can vary from person to person. Some individuals may be more sensitive to the effects of caffeine, while others may not experience any negative effects at all.

One factor that can influence the relationship between coffee and inflammation is the amount of coffee consumed. Research suggests that drinking one to two cups of coffee per day may provide health benefits without causing inflammation. However, consuming excessive amounts of coffee may increase the risk of inflammation and other health problems.

Another factor to consider is the way in which coffee is consumed. Adding sugar and milk to coffee can increase inflammation due to the inflammatory properties of sugar. Therefore, it is recommended to stick to natural sweeteners or consume coffee black to minimize the risk of inflammation.

Overall, the relationship between coffee and inflammation is complex and can vary based on individual factors. While coffee may provide health benefits, it is important to consume it in moderation and pay attention to any negative effects it may have on the body.

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