The 10 Best Nootropics Supplements for Brain Health in 2023

By Last Updated: October 24th, 202316.5 min readViews: 2102

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About the Author: Daryl Stubbs
Daryl Stubbs
Daryl Stubbs has won a 2x national awards in athletic therapy and has been named best massge therapy clinic and physiotherapist/rehab clinic for Victoria in 2022. With a journey that took him from anxiety and insecurity to self-confidence and success, Daryl inspires others to overcome their health concerns and achieve their goals. He shares his experiences and insights through his writing and work experience, helping others to unlock their full potential. Follow Daryl's journey as he continues to challenge himself and strive towards personal and professional growth.

Imagine if you could unlock your brain’s full potential – boosting your focus, memory, and mental performance to new heights. With the best nootropics supplements, this vision becomes a reality. As the demand for cognitive enhancement grows, nootropic supplements have emerged as a promising solution to support brain health and optimize cognitive function. In this comprehensive guide, we will explore the world of nootropics, their benefits, and the top 10 best nootropics supplements for cognitive enhancement in 2023. Get ready to discover the power of nootropics to boost brain function and transform your mental performance!

Key TakeAway The Best Nootropic Supplements

The best brain supplements include alpha brain, Viomes personalized supplements, Cymbiotika’s Golden mind, and Qualia mind.

Alpha Brain is a nootropic supplement that contains herbal extracts, vitamins, and minerals to boost cognitive performance and increase overall brain health.

Viome is a gut health testing company that uses artificial intelligence to analyze an individual’s gut biology to gain insights into their health. Not only do they analyze your gut microbiome, but you also get personal food and supplement recommendations. This is probably the best nootropic stack because we know that to get the best results for short-term memory, long-term brain health, and other cognitive benefits, we need to sleep well, eat nutritious food, and exercise. It’s the best option on the market today because you get a personalized recommendation from objective data, not a questionnaire that we know is incredibly suspect in its results. You get so much more information about your health than any other supplement out there.

Cymbiotika Golden Mind is a liquid nootropic supplement that stimulates peak mental performance and protects against age-related cognitive decline. This formula supports intestinal health and strengthens the gut-brain axis by enhancing communication between the gastrointestinal tract and the central nervous system.

Qualia Mind is a nootropic supplement that contains 28 ingredients supported by research to work with the brain’s existing chemistry in support of its key functions. It provides a sustained boost in focus and memory without causing that “wired” feeling or drowsiness

Understanding Nootropics: Boosting Brain Power

The human brain is a marvel of nature, capable of processing vast amounts of information and orchestrating countless processes simultaneously. However, as we age, our brain function tends to decline, leading to issues such cognitive functions such as memory loss and cognitive decline.

In response, many individuals have turned to nootropic supplements to help support healthy brain function and enhance cognitive performance. But what exactly are nootropics, and how do they work?

Defining Nootropics

Nootropics, also known as “smart drugs” or cognitive enhancers, are substances that promote cognitive enhancement, mental acuity, and brain health. These compounds, which can be derived from natural sources like plants and herbs or created synthetically, have been shown to enhance both cognitive ability and performance by improving memory, focus, and mental clarity. Some well-known examples of natural nootropics include Ginkgo Biloba, Rhodiola Rosea, and Omega-3 fatty acids, while synthetic nootropics like Adderall and Ritalin are often prescribed for attention deficit hyperactivity disorder (ADHD).

One of the reasons why nootropics have garnered so much attention is their potential to protect the brain from age-related cognitive decline. For instance, Phosphatidylserine, a key ingredient in Mind Lab Pro’s formula, may help reduce the risk of cognitive decline and brain degeneration. A study involving 101 participants with age-related memory complaints revealed positive changes in their performance on various tests related to memory and attention. They had taken daily dose of Rhodiola Rosea Extract.

Benefits of Using Nootropics

The benefits of using nootropics extend far beyond merely improving cognitive function. These supplements have been shown to boost mental performance, enhance memory and learning abilities, elevate mood, and reduce stress. For example, Rhodiola rosea has been suggested to provide improved mental performance and reduced mental fatigue. Additionally, nootropics like L-theanine have been shown to increase serotonin and dopamine levels in the body, which can help improve cognitive, improve mental performance, and elevate mood.

When it comes to choosing a nootropic supplement, it is crucial to consider the quality and safety of the product, as well as the recommended dosage and cost-effectiveness. By carefully selecting a nootropic supplement that aligns with your specific needs and preferences, you can unlock your brain’s full potential and experience a noticeable improvement in your cognitive abilities.

Types of Nootropics: Natural vs Synthetic

Nootropics can be broadly classified into two categories: natural and synthetic. Each type offers its own unique set of advantages and potential drawbacks, making it essential for individuals to understand the differences between the two before selecting a nootropic supplement.

In this section, we will discuss the characteristics of both natural and synthetic nootropics, their respective benefits, and potential side effects.

Natural Nootropics

Natural nootropics are derived from plants, herbs, and food sources, and have been used in traditional medicine for centuries to enhance cognitive and mental function alone. These substances tend to produce fewer side effects than synthetic alternatives, making them a popular choice for those seeking a gentler approach to cognitive enhancement. Examples of natural nootropics include caffeine, ginkgo biloba, and omega-3 fatty acids, which have been shown to improve cognitive function, mood, and energy levels.

Furthermore, certain natural nootropics, such as Rhodiola Rosea, have been shown to enhance energy levels and mitigate stress and fatigue. By supporting healthy brain function and providing essential nutrients, natural nootropics can offer a holistic approach to cognitive enhancement that is both safe and effective.

Synthetic Nootropics

On the other hand, synthetic nootropics are chemically engineered compounds that are more potent than their natural counterparts. These substances typically exhibit greater potency and have the potential to produce more dramatic effects on memory and cognitive function alone. However, their increased potency also comes with a higher risk of side effects, making it essential for individuals to exercise caution when using synthetic nootropics.

Examples of synthetic nootropics include Adderall and Ritalin, which are often prescribed for attention deficit hyperactivity disorder (ADHD). While these substances can provide significant cognitive enhancements, they may also carry a risk of adverse effects, such as headaches, nausea, sleeplessness, anxiety, and depression.

It is important to weigh the potential benefits of synthetic nootropics against their potential risks and consult a healthcare professional before using these substances.

Key Ingredients to Look for in Nootropic Supplements

When selecting a nootropic supplement, it is essential to consider the key ingredients that contribute to its effectiveness. These ingredients may include substances like caffeine, L-theanine, and Bacopa Monnieri, which have been shown to provide various cognitive-enhancing effects.

In this section, we will discuss the role of these key ingredients in nootropic supplements and their potential benefits for cognitive function.


Caffeine is a widely used nootropic ingredient that is found in many popular beverages, such as coffee and tea. It works by blocking adenosine receptors in the brain, which reduces feelings of fatigue and enhances concentration and mental alertness. Caffeine is frequently included in nootropic supplements due to its ability to stimulate cognitive performance and provide a temporary boost in mental energy.

However, it is crucial to be mindful of caffeine intake, as excessive consumption can lead to side effects such as jitteriness, increased heart rate, and insomnia.


L-theanine is an amino acid commonly found in green tea. It has been studied and it was revealed that the compound promotes relaxation without causing drowsiness. Research suggests that L-theanine may improve nerve signal reception, memory and learning, mood, stress and anxiety levels, responsiveness, focus, concentration, and longevity.

When combined with caffeine, L-theanine can help increase mental alertness and precision when multitasking, thereby improving cognitive performance. This synergistic effect makes L-theanine an essential ingredient to look for in nootropic supplements.

Bacopa Monnieri

Bacopa Monnieri is an aquatic plant that has been utilized in Ayurvedic medicine for centuries due to its nootropic properties. Studies have shown that Bacopa Monnieri can promote a healthy stress response and may demonstrate cognitive enhancement capabilities, with the potential to reduce oxidative damage.

This makes Bacopa Monnieri a valuable ingredient to consider when selecting a nootropic supplement for cognitive enhancement.

Top 10 Nootropic Supplements for 2023: Reviews and Comparisons

With a myriad of nootropic supplements available on the market, it can be challenging to determine which ones are most effective and suitable for your needs. To help you make an informed decision, we have compiled a list of the top 10 nootropic supplements for 2023 based on factors such as brand reputation, customer trust, cost per serving, and the quality and efficacy of the nootropic components.

In this section, we will provide an overview of each supplement, highlighting their unique features and benefits.

Onnit Alpha Brain

Onnit Alpha Brain is a popular nootropic supplement designed to enhance cognitive, improve brain function, and promote a positive mood. Its formula contains a blend of ingredients such as L-tyrosine and L-theanine, which have been shown to increase serotonin and dopamine levels in the body, leading to improved cognitive performance and elevated mood.

With its well-rounded formula and positive customer feedback, Onnit Alpha Brain is a top contender for those seeking a nootropic supplement to support their cognitive enhancement goals.

BrainMD Brain & Memory Power Boost

BrainMD Brain & Memory Power Boost is a potent nootropic supplement designed to support healthy brain and memory performance. Its unique formula features a combination of nutrients that have been clinically proven to enhance the brain’s energy and protect circulation, as well as Ginkgo Biloba Extract to support healthy blood and flow to the brain.

Manufactured in FDA registered facilities, BrainMD products are doctor-formulated, ensuring the highest quality and safety standards. If you’re looking for a supplement to support your brain’s health and boost memory too, BrainMD Brain & Memory Power Boost is a solid choice.

Cymbiotika Golden Mind

Cymbiotika Golden. Mind is a plant-based supplement formulated to support peak mental performance, protect against age-related cognitive decline, and strengthen the gut-brain axis. Its unique blend of ingredients includes almonds, DHA Omega-3, turmeric, maca, MCT oil, prebiotics, and protein, all of which work together to improve intestinal health and enhance communication between the gastrointestinal tract and the central nervous system.

With its innovative formula and focus on gut-brain health, Cymbiotika Golden Mind is an excellent option for those seeking a holistic approach to cognitive enhancement.

Qualia Mind

Qualia Mind is a comprehensive nootropic supplement that combines vitamins, minerals, amino acids, choline donors, and herbal ingredients to create a powerful cognitive-enhancing formula. Designed to boost mental performance by addressing cognition from a variety of perspectives, Qualia Mind can help improve memory and learning abilities, improve mental function, elevate mood, and reduce stress.

With its diverse ingredients and well-rounded formula, Qualia Mind is an excellent choice for individuals seeking a nootropic supplement that covers all bases when it comes to cognitive enhancement.

Viome Prebiotic and Probiotic Supplements

Viome Prebiotic and Probiotic Supplements offer a personalized approach to cognitive enhancement by focusing on the gut-brain axis. These supplements contain a combination of strain-specific probiotics and prebiotic fibers to support a balanced gut microbiome, which has been shown to impact cognitive, enhance brain function, and overall health.

By enhancing digestion, increasing immunity, and sustaining a beneficial balance of bacteria in the gut, Viome Prebiotic and Probiotic Supplements provide a unique and personalized approach to cognitive enhancement improve brain health.

HostDefense MycoBotanicals

HostDefense MycoBotanicals is a line of mushroom supplements that may support the immune system, reduce stress and fatigue, and provide assistance against daily environmental assaults. Its formula contains certified organic herbs and mushrooms, such as Ginkgo, Bacopa, Gotu Kola, Lion’s Mane, and Reishi, which work together to support overall health and cognitive function.

With its focus on natural ingredients and immune support, HostDefense MycoBotanicals is an excellent option for those seeking a nootropic supplement with well-rounded health benefits.

Rritual Lions Mane

Rritual Lions. Mane is a product from Rritual Superfoods that features the potential cognitive-enhancing benefits of Lion’s Mane Mushroom. While there is limited information available on this specific product, Lion’s Mane Mushroom is known for its ability to induce a 60.6% neurite outgrowth, which can support active brain cells and promote cognitive enhancement.

As a result, RRITUAL Lions Mane may be worth considering for individuals seeking the cognitive-enhancing benefits of Lion’s Mane Mushroom in their nootropic supplement.

What is the best brain nootropic?

Alpha Brain is a popular nootropic supplement that claims to improve cognitive functions such as memory, focus, and mental processing speed. It is formulated with a blend of natural ingredients, including acetyl-L-carnitine, Bacopa monnieri, oat straw extract, phosphatidylserine, and L-theanine, among others. These ingredients are believed to regulate neurotransmitter production and alpha brain wave activity, resulting in various improvements in cognitive health.

Alpha Brain has a large following and has sold over a million bottles and they put their money where their mouth is and have a double-blind study showing it works. Some reviews suggest that it is not as effective as other options in the market. The study was for 6 weeks, so you’ll need to order two bottles for it to show those results.

Moreover, some studies have shown that Alpha Brain may improve short-term cognitive function and memory due to its effectively-dosed ingredients.

This suggests that while Alpha Brain may be a best nootropic supplement, with research on the product and not the ingredients – like deceptive companies use.

In conclusion, Alpha Brain is a well-known nootropic supplement with a blend of natural ingredients that may improve cognitive functions such as memory, focus, and mental processing speed

Which brain supplement works the best?

Some supplements have been suggested to improve cognitive function and support healthy brain function. Here are some of the best brain supplements according to the search results:

Lions Mane: This supplement has been clinically proven to improve memory recall, focus, clarity of thought, and overall cognitive function. Freshcap Lions Mane is the mushroom I use for my brain.

Fish oils: Fish oils are rich in omega-3 fatty acids, which may help support healthy brain function.

Resveratrol: This supplement is found in red wine and has been suggested to have neuroprotective effects.

Creatine: Creatine is a supplement commonly used by athletes to improve physical performance, but it may also have cognitive benefits. I love Cymbiotika’s Creatine

Caffeine: Caffeine is a stimulant that can improve alertness and focus. You can also use Foursigmatic’s lions mane mushroom coffee. It’s their “think” coffee, which pairs caffeine with lions mane together.

Phosphatidylserine: This supplement could improve thinking skills and memory and help combat the decline in brain function as you age.

Vitamin B12: Vitamin B12 is essential for healthy brain function and may help improve cognitive function in older adults. Cymbiotika’s B6 and B12 is the best on the market and one of the best mood boosting supplements.

Natural Stacks: This supplement is a fast-acting formula that may help improve cognitive function. Easily the best nootropic supplement stack is Viomes supplements.

Factors to Consider When Choosing a Nootropic Supplement

When selecting a nootropic supplement, it is essential to consider certain factors to ensure that you choose a product that is both safe and effective. These factors include the quality and safety of the product, recommended dosage, and cost-effectiveness.

In this section, we will discuss each of these factors in more detail, providing guidance on how to choose the best nootropic supplement for your needs.

Quality and Safety

When it comes to quality and safety, it is crucial to consider the purity and potency of the ingredients used in the nootropic supplement, as well as any potential side effects or interactions with medications. It is also essential to ensure that the product is free of any harmful contaminants and has been tested for quality and efficacy.

By carefully considering the quality and safety of a nootropic supplement, you can minimize the risk of adverse effects and maximize the potential cognitive-enhancing benefits.

Dosage Recommendations

It is essential to adhere to the recommended dosage instructions for nootropic supplements, as exceeding the recommended dose can be detrimental to one’s health. Dosage recommendations may vary depending on the specific supplement, so it is imperative to consult the supplement label or a healthcare professional for guidance on the appropriate dosage for your needs.

By following the recommended dosage, you can ensure that you are consuming the nootropic supplement safely and effectively.

Price and Value

Finally, when selecting a nootropic supplement, it is important to consider the price and value of the product. While some nootropic supplements may be more expensive than others, it is crucial to weigh the potential benefits against the cost to determine if the product is worth the investment.

Additionally, it is worth considering factors such as brand reputation and customer trust, as well as any guarantees or return policies offered by the manufacturer, such as a money-back guarantee.

By considering the price and value of a nootropic supplement, you can make an informed decision and choose a product that aligns with your budget and cognitive enhancement goals.

Precautions and Potential Side Effects

While nootropic supplements can offer significant cognitive-enhancing benefits, it is essential to be aware of potential side effects and precautions when using these substances.

In this section, we will discuss common side effects associated with nootropic supplements, potential interactions with medications, and general precautions to consider when using these products.

Common Side Effects

Although side effects of nootropics are generally rare and mild, some individuals may experience adverse effects such as overstimulation, anxiety, or gastrointestinal issues. It is essential to listen to your body and discontinue the use of a nootropic supplement if you experience any adverse reactions.

It is important to consult a healthcare professional before using nootropic supplements. This is especially true if you have existing medical conditions or are taking any medications.

Interactions with Medications

While it is rare for interactions to occur between nootropic supplements and medications, it is crucial to be aware of the potential risks and consult a healthcare professional before using these substances. Interactions between nootropic supplements and medications may result in adverse effects, including an increased risk of side effects, reduced efficacy of medications, or even hazardous drug interactions.

By consulting with a healthcare professional and carefully reviewing the ingredients in your nootropic supplement, you can minimize the risk of potential interactions and ensure that you are using these products safely.


In conclusion, nootropic supplements offer a promising solution for individuals seeking to enhance their cognitive performance, improve memory, and support overall brain health. By understanding the different types of nootropics, considering key ingredients, and being mindful of factors such as quality, safety, dosage, and price, you can make an informed decision and choose the best nootropic supplement to further brain performance and unlock your brain’s full potential. Embark on your journey toward peak mental performance today!

Frequently Asked Questions

What is the most powerful nootropic in the world?

Nooceptin is indisputably the most powerful nootropic on the market. Combining comprehensive cognitive enhancement with excellent quality ingredients and an unparalleled safety profile, it stands far above the competition as the ideal choice for those seeking maximum brain benefits.

It is formulated with a unique blend of natural ingredients that have been clinically proven to improve focus, memory, and overall cognitive performance. The combination of these ingredients provides a synergy.

What is the strongest nootropic for ADHD?

Based on feedback from the community, Modafinil has been identified as the strongest nootropic for treating ADHD. It is a wakefulness-promoting agent that can help increase focus and energy in those with ADD and narcolepsy.

Which brain supplement works the best?

Based on scientific evidence and expert advice, Bacopa Monnieri appears to be the best brain supplement for improving cognitive function. It is known to improve memory formation, reduce stress, and enhance overall cognitive functioning.

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